By Michelle Roberts Health reporter via www.news.bbc.co.uk
Scientists have unlocked the entire genetic code of two of the most common cancers – skin and lung – a move they say could revolutionise cancer care.
Not only will the cancer maps pave the way for blood tests to spot tumours far earlier, they will also yield new drug targets, says the Wellcome Trust team.
Scientists around the globe are now working to catalogue all the genes that go wrong in many types of human cancer.
The UK is looking at breast cancer, Japan at liver and India at mouth.
China is studying stomach cancer, and the US is looking at cancers of the brain, ovary and pancreas.
The International Cancer Genome Consortium scientists from the 10 countries involved say it will take them at least five years and many hundreds of thousands of dollars to complete this mammoth task.
But once they have done this, patients will reap the benefits.
Professor Michael Stratton, who is the UK lead, said: “These catalogues are going to change the way we think about individual cancers.
“By identifying all the cancer genes we will be able to develop new drugs that target the specific mutated genes and work out which patients will benefit from these novel treatments.
“We can envisage a time when following the removal of a cancer cataloguing it will become routine.”
It could even be possible to develop MoT-style blood tests for healthy adults that can check for tell-tale DNA patterns suggestive of cancer.
The scientists found the DNA code for a skin cancer called melanoma contained more than 30,000 errors almost entirely caused by too much sun exposure.
Most of the time the mutations will land in innocent parts of the genome, but some will hit the right targets for cancer
The lung cancer DNA code had more than 23,000 errors largely triggered by cigarette smoke exposure.
From this, the experts estimate a typical smoker acquires one new mutation for every 15 cigarettes they smoke.
Although many of these mutations will be harmless, some will trigger cancer.
Wellcome Trust researcher Dr. Peter Campbell, who conducted this research, published in the journal Nature, said: “It’s like playing Russian roulette.
“Most of the time the mutations will land in innocent parts of the genome, but some will hit the right targets for cancer.”
By quitting smoking, people could reduce their cancer risk back down to “normal” with time, he said.
The suspicion is lung cells containing mutations are eventually replaced with new ones free of genetic errors.
By studying the cancer catalogues in detail, the scientists say it should be possible to find exactly which lifestyle and environmental factors trigger different tumours.
Treatment and Prevention
Tom Haswell, who was successfully treated 15 years ago for lung cancer, believes the research will benefit the next generation:
“For future patients I think it’s tremendous news because hopefully treatments can be targeted to their particular genome mutations, hopefully… reducing some of the side effects we get”.
Cancer experts have applauded the work.
The Institute of Cancer Research said: “This is the first time that a complete cancer genome has been sequenced and similar insights into other cancer genomes are likely to follow.
“As more cancer genomes are revealed by this technique, we will gain a greater understanding of how cancer is caused and develops, improving our ability to prevent, treat and cure cancer.”
Professor Carlos Caldas, from Cancer Research UK’s Cambridge Research Institute called the research “groundbreaking”.
“Like molecular archaeologists, these researchers have dug through layers of genetic information to uncover the history of these patients’ disease.
“What is so new in this study is the researchers have been able to link particular mutations to their cause.
“The hope and excitement for the future is that we will eventually have detailed picture of how different cancers develop, and ultimately how better to treat and prevent them.”
That is a lot of research, money, and power wrapped up in that when there is nothing spent on confirming natural treatments for cancer, or more, ways to avoid it. This seems an odd article to have here since it ignores who has control of that mapping (the pharmaceutical industry and biotech) and how much this super-dooper research gives people the impression that only through monstrously complex and expensive science and its patented drugs and painful treatments, can people have a chance against cancer. And all that ignores how much cancer is created by these same companies through GMOs and drugs and vaccines to begin with. When the tobacco industry was faced with the public knowing the truth about tobacco causing cancer and people began quitting, they upped the nicotine level in cigarettes. Who provided that nicotine? If it was the drug companies, they are making cancer on one hand and claiming they need billions in research to treat it. The latest WHO scandal – after the swine flu one now being investigated in Europe as the worst scandal in medical history – is a plan for global taxes to fund their research and manufacturing in the third world, which will be patented and benefit them. So, I find this article here incongruous and disturbing.
Our new age of democracy is just an oxymoron but with new sophisticated technology, we can achieve a utopia.
What are the 4 main components, in the human genome, that cause cancer? There may be more than 4 but what are the 4 most relevant? If there are more components, in the human genome, that causes cancer what are the other factors?